A-Scan Advantage​ at a Glance 

  • Optical Scanning:  A-Scan introduces the first oxygen scanning needle-probe that uses an optical scanner. Optical scanning makes the measurement of the pO2 profile easy, precise, and robust.

  • Automated depth scanning: A-Scan needle's design allows for a fully automated scanning along the needle's axis.

  • Internal scanning:  A-Scan needles feature an internal probe, embedded inside the needle. This design eliminates the need to mechanically translate the needle's tip in tissue thereby avoiding excessive tissue damage.

  • Applications: 

    • Pre-clinical testing

    • Small animal studies

    • Tissue engineering

 

 

A-Scan tissue oxygen scanner is uniqely designed for reseachers. It combines a rugged design for repeated use in tissue with an easy and intuitive depth scanning.

The sensor is housed inside an hypodermic needle having a side-window along its axis. Oxygen level can be measured along the side window at a fine resolution (0.2 mm). Automatic scanning can be programmed and repeated periodically with NO relative motion between the needle and the tissue. This feature is ideal for pre-clinical studies in animal models. Oxygen gradients are accurately recorded in a form of a full pO2 depth profile. Dynamic response to treatment or other ques can be explored by programming repeated scans in small time intervals.

 

Technical Specifications (highlights)

  • Scan length: 20, 40, or 60 mm.

  • Needle diamter: 0.36 mm.

  • Full scan in under 3 minutes (20 mm at 0.2 mm step).

  • Number of repeated scans: Unlimited

  • System compatibility: PC (Windows 10 / 11)

  • pO2 measurement range: 0 to 160 mmHg.

   

Scanning Tissue Oxygen Probe

An Application Example: A scan through a cancer tumor in a mouse cancer model demonstrating a sharp decrease of pO2 in the tumor core. For more details see S. Ashkenazi et. al.

Ashkenazi S., Cho D., Song C.W. (2021) Scanning Tissue Oxygen Needle Probe. In: Nemoto E.M., Harrison E.M., Pias S.C., Bragin D.E., Harrison D.K., LaManna J.C. (eds) Oxygen Transport to Tissue XLII. Advances in Experimental Medicine and Biology, vol 1269. Springer, Cham. https://doi.org/10.1007/978-3-030-48238-1_8

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A-Scan system and a scanning needle probe